Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy

DOI Web Site 被引用文献1件 参考文献49件
  • Richi Nakatake
    Department of Surgery, Kansai Medical University, Hirakata 573-1010, Osaka, Japan
  • Tetsuya Okuyama
    Department of Surgery, Kansai Medical University, Hirakata 573-1010, Osaka, Japan
  • Morihiko Ishizaki
    Department of Surgery, Kansai Medical University, Hirakata 573-1010, Osaka, Japan
  • Hidesuke Yanagida
    Department of Surgery, Kansai Medical University, Hirakata 573-1010, Osaka, Japan
  • Hiroaki Kitade
    Department of Surgery, Kansai Medical University, Hirakata 573-1010, Osaka, Japan
  • Katsuhiko Yoshizawa
    Department of Innovative Food Sciences, School of Food Sciences and Nutrition, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya 663-8558, Hyogo, Japan
  • Mikio Nishizawa
    Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Shiga, Japan
  • Mitsugu Sekimoto
    Department of Surgery, Kansai Medical University, Hirakata 573-1010, Osaka, Japan

書誌事項

公開日
2024-01-14
資源種別
journal article
権利情報
  • https://creativecommons.org/licenses/by/4.0/
DOI
  • 10.3390/nu16020256
公開者
MDPI AG

説明

<jats:p>A standardized extract of cultured Lentinula edodes mycelia (ECLM, AHCC®) has been shown to have beneficial effects on organ metabolism. ECLM has been indicated to have liver protective properties by suppressing inflammatory responses. The pathogenesis of hepatic ischemia-reperfusion injury is thought to involve the induction of inflammatory mediators. However, whether ECLM affects inflammatory mediators caused by warm hepatic ischemia-reperfusion injury and partial hepatectomy (HIRI+PH) has not been clarified. In this study, we evaluated the protective effects of ECLM against liver damage caused by HIRI+PH. Rats were fed a normal diet (HIRI+PH) or a normal diet with 2% ECLM (HIRI+PH and ECLM) for ten days, then the liver and duodenal ligament were clamped and subjected to 15 min of hepatic ischemia. After 70% hepatectomy, the inflow occlusion was released, and liver and blood samples were collected at 3, 6, and 24 h. The effect of ECLM on mortality induced by 30 min of ischemia and hepatectomy was evaluated. The results showed that ECLM attenuated pathological liver damage, including apoptosis, in the rats treated with HIRI+PH, and decreased serum aminotransferase activity; ECLM decreased mRNA levels of the inflammation-related genes inducible nitric oxide synthase and C-X-C motif chemokine ligand 1, and increased mRNA levels of interleukin 10, an anti-inflammatory cytokine; ECLM increased hepatocyte growth factor mRNA levels and Ki-67 labeled nuclei in the liver at 24 h; ECLM significantly reduced HIRI+PH-induced mortality. In conclusion, ECLM may prevent HIRI+PH-induced liver injury in part by suppressing various inflammatory responses and promoting liver regeneration.</jats:p>

収録刊行物

  • Nutrients

    Nutrients 16 (2), 256-, 2024-01-14

    MDPI AG

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