Current status of liver transplantation for <scp>non‐B non‐C</scp> liver cirrhosis and hepatocellular carcinoma
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- Takahiro Nishio
- Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan
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- Takashi Ito
- Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan
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- Koichiro Hata
- Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan
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- Kojiro Taura
- Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan
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- Etsuro Hatano
- Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan
書誌事項
- 公開日
- 2022-08-23
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1002/ags3.12612
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Recently, non‐B non‐C chronic liver diseases, including alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), have markedly increased worldwide. Liver transplantation (LT) is an effective curative therapy for hepatocellular carcinoma (HCC) as well as decompensated liver cirrhosis. In Japan, where the source of liver grafts is strongly dependent on living donors, efforts have been made to unify the indications for eligibility of HCC patients for LT, leading to the development of 5‐5‐500 criteria. Along with the expansion of eligibility for LT, the current changing trends in underlying liver diseases of LT recipients, which are related to the rising tide of non‐B non‐C cirrhosis and HCC, are highlighting the importance of peri‐transplant management of patients with various comorbidities. The post‐LT prognosis of patients with ALD is significantly affected by de novo malignancies and metabolic syndrome‐related complications as well as posttransplant alcohol relapse. NAFLD/NASH patients often suffer from obesity, type 2 diabetes mellitus, and other metabolic syndrome‐related disorders, and nonneoplastic factors such as cardiovascular events and recurrence of NAFLD/NASH have a significant impact on post‐LT outcomes. Patient management in the peri‐transplant period as well as risk assessment for LT are key to improving post‐LT outcomes in the era of a growing number of cases of LT for non‐B non‐C liver diseases.</jats:p>
収録刊行物
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- Annals of Gastroenterological Surgery
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Annals of Gastroenterological Surgery 7 (1), 42-52, 2022-08-23
Wiley
