Crosstalk within and beyond the Polycomb repressive system

DOI PDF 研究データあり 参考文献173件 オープンアクセス
  • Tianyi Hideyuki Shi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo 1 , Tokyo, Japan
  • Hiroki Sugishita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo 1 , Tokyo, Japan
  • Yukiko Gotoh
    Graduate School of Pharmaceutical Sciences, The University of Tokyo 1 , Tokyo, Japan

書誌事項

公開日
2024-03-20
資源種別
journal article
権利情報
  • https://creativecommons.org/licenses/by/4.0/
DOI
  • 10.1083/jcb.202311021
公開者
Rockefeller University Press

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説明

<jats:p>The development of multicellular organisms depends on spatiotemporally controlled differentiation of numerous cell types and their maintenance. To generate such diversity based on the invariant genetic information stored in DNA, epigenetic mechanisms, which are heritable changes in gene function that do not involve alterations to the underlying DNA sequence, are required to establish and maintain unique gene expression programs. Polycomb repressive complexes represent a paradigm of epigenetic regulation of developmentally regulated genes, and the roles of these complexes as well as the epigenetic marks they deposit, namely H3K27me3 and H2AK119ub, have been extensively studied. However, an emerging theme from recent studies is that not only the autonomous functions of the Polycomb repressive system, but also crosstalks of Polycomb with other epigenetic modifications, are important for gene regulation. In this review, we summarize how these crosstalk mechanisms have improved our understanding of Polycomb biology and how such knowledge could help with the design of cancer treatments that target the dysregulated epigenome.</jats:p>

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