Intrinsic contractile dysfunction due to impaired sarcoplasmic reticulum Ca<sup>2+</sup> release in compensatory hypertrophied muscle fibers following synergist ablation

DOI Web Site 参考文献89件
  • Nao Tokuda
    Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan
  • Daiki Watanabe
    Graduate School of Sport and Health Sciences, Osaka University of Health and Sport Sciences, Osaka, Japan
  • Azuma Naito
    Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan
  • Nao Yamauchi
    Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan
  • Yuki Ashida
    Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan
  • Arthur J. Cheng
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada
  • Takashi Yamada
    Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan

書誌事項

公開日
2023-09-01
資源種別
journal article
DOI
  • 10.1152/ajpcell.00127.2023
公開者
American Physiological Society

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説明

<jats:p> Synergist ablation (SA) has widely been used to understand the mechanisms behind skeletal muscle hypertrophy. However, compensatory hypertrophied muscles display intrinsic contractile dysfunction, i.e., a hallmark of overuse. Here, we demonstrate that SA-induced compensatory hypertrophy is accompanied by muscle weakness due to impaired sarcoplasmic reticulum Ca<jats:sup>2+</jats:sup> release. This dysfunction may be caused by the degradation of triad proteins due to the reciprocal amplification of reactive oxygen species and Ca<jats:sup>2+</jats:sup> signaling at the junctional space microdomain. </jats:p>

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