MRI Contrasting Agent Based on Mn-MOF-74 Nanoparticles with Coordinatively Unsaturated Sites
書誌事項
- 公開日
- 2023-01-18
- 資源種別
- journal article
- 権利情報
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- https://www.springernature.com/gp/researchers/text-and-data-mining
- https://www.springernature.com/gp/researchers/text-and-data-mining
- DOI
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- 10.1007/s11307-023-01801-0
- 公開者
- Springer Science and Business Media LLC
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説明
The development of magnetic resonance imaging (MRI) contrasting agents (CAs) that are safer and have a higher relaxivity than Gd(III)-based agents is a significant research topic. Herein, we propose the use of a Mn-based metal organic framework (MOF), Mn-MOF-74, characterized by a safe paramagnetic center, a coordinatively unsaturated site (CUS) for aquation, and a long rotational correlation time, endowing high relaxivity. Furthermore, biocompatibility and delivery to the tumor are generally expected for MOFs that are obtainable in the nanometer size range.Drop-wise mixing of 2,5-dihydroxyterephthalic acid (DHTP) and Mn(II) acetate yielded Mn-MOF-74 with a diameter of 150 nm, which was then modified with 1-fivefold higher amounts of poly(ethylene glycol) (M.W. = 5000) to afford MOFs stably dispersed in water for at least 24 h.The longitudinal and transverse relaxivity of the PEG-modified MOF was in the range of rThese results suggest that PEG-Mn-MOF-74 can be passively delivered to tumors and can act as a high-relaxivity T
収録刊行物
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- Molecular Imaging and Biology
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Molecular Imaging and Biology 25 (5), 968-976, 2023-01-18
Springer Science and Business Media LLC
