Cage‐Shaped Phosphites Having <i>C</i><sub>3</sub>‐Symmetric Chiral Environment: Steric Control of Lewis Basicity and Application as Chiral Ligands in Rhodium‐Catalyzed Conjugate Additions

DOI Web Site 被引用文献1件 参考文献90件
  • Xiao Liu
    Department of Applied Chemistry Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan
  • Kazuma Tomita
    Department of Applied Chemistry Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan
  • Akihito Konishi
    Department of Applied Chemistry Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan
  • Makoto Yasuda
    Department of Applied Chemistry Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan

書誌事項

公開日
2023-10-16
資源種別
journal article
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/chem.202302611
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Designing chiral ligands with an axial symmetry higher than <jats:italic>C</jats:italic><jats:sub>2</jats:sub>‐rotational symmetry is one of the most crucial approaches to improving enantioselectivity in asymmetric synthesis. Herein, <jats:italic>C</jats:italic><jats:sub>3</jats:sub>‐symmetric chiral cage‐shaped phosphites are reported. Their Lewis basicity and chiral environment are precisely controlled by the tethered group. The cage‐shaped phosphites successfully worked as chiral ligands in Rh‐catalyzed asymmetric conjugate additions, realizing acceptable yields with excellent enantioselectivity, and were used to synthesize a pharmacologically important molecule.</jats:p>

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