Flowmicro In‐Line Analysis‐Driven Design of Reactions Mediated by Unstable Intermediates: Flash Monitoring Approach

DOI Web Site Web Site 被引用文献4件 参考文献66件
  • Yosuke Ashikari
    Department of Chemistry, Faculty of Science Hokkaido University Kita-10 Nishi-8 Kita-ku, Sapporo Hokkaido 060-0810 Japan
  • Rikako Yoshioka
    Department of Chemistry, Faculty of Science Hokkaido University Kita-10 Nishi-8 Kita-ku, Sapporo Hokkaido 060-0810 Japan
  • Yuya Yonekura
    Department of Chemistry, Faculty of Science Hokkaido University Kita-10 Nishi-8 Kita-ku, Sapporo Hokkaido 060-0810 Japan
  • Dong‐eun Yoo
    Department of Chemistry, Faculty of Science Hokkaido University Kita-10 Nishi-8 Kita-ku, Sapporo Hokkaido 060-0810 Japan
  • Kazuhiro Okamoto
    Department of Chemistry, Faculty of Science Hokkaido University Kita-10 Nishi-8 Kita-ku, Sapporo Hokkaido 060-0810 Japan
  • Aiichiro Nagaki
    Department of Chemistry, Faculty of Science Hokkaido University Kita-10 Nishi-8 Kita-ku, Sapporo Hokkaido 060-0810 Japan

書誌事項

公開日
2024-03-12
資源種別
journal article
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#am
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/chem.202303774
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>The direct observation of reactive intermediates is an important issue for organic synthesis. However, intermediates with an extreme instability are hard to be monitored by common spectroscopic methods such as FTIR. We have developed synthetic method utilizing flow microreactors, which enables a generation and reactions of unstable intermediates. Herein we report that, based on our flowmicro techniques, we developed an in‐line analysis method for reactive intermediates in increments of milliseconds. We demonstrated the direct observation of the living and dead species of the anionic polymerization of alkyl methacrylates. The direct information of the living species enabled the anionic polymerization and copolymerization of oligo(ethylene glycol) methyl ether methacrylates, which is the important but difficult reaction in the conventional method.</jats:p>

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