Serological and Molecular Epidemiology of Chikungunya Virus Infection in Vietnam, 2017–2019
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- Thanh Vu Nguyen
- Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
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- Mya Myat Ngwe Tun
- Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
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- Minh Thang Cao
- Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam
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- Huy Manh Dao
- Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam
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- Chan Quang Luong
- Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam
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- Thi Kim Loan Huynh
- Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam
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- Thi Thanh Thuong Nguyen
- Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam
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- Thi Nhu Dao Hoang
- Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam
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- Kouichi Morita
- Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
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- Thi Quynh Mai Le
- National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam
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- Quang Duy Pham
- Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam
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- Yuki Takamatsu
- Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
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- Futoshi Hasebe
- Vietnam Research Station, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
書誌事項
- 公開日
- 2023-10-08
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/v15102065
- 公開者
- MDPI AG
説明
<jats:p>Chikungunya fever is an acute febrile illness caused by the chikungunya virus (CHIKV), which is transmitted by Aedes mosquitoes. Since 1965, only a few studies with limited scope have been conducted on CHIKV in Vietnam. Thus, this study aimed to determine the seroprevalence and molecular epidemiology of CHIKV infection among febrile patients in Vietnam from 2017 to 2019. A total of 1063 serum samples from 31 provinces were collected and tested for anti-CHIKV IgM and IgG ELISA. The 50% focus reduction neutralization test (FRNT50) was used to confirm CHIKV-neutralizing antibodies. Quantitative real-time RT–PCR (RT–qPCR) was performed to confirm the presence of the CHIKV genome. The results showed that 15.9% (169/1063) of the patients had anti-CHIKV IgM antibodies, 20.1% (214/1063) had anti-CHIKV IgG antibodies, 10.4% (111/1063) had CHIKV-neutralizing antibodies, and 27.7% (130/469) of the samples were positive in RT–qPCR analysis. The E1 CHIKV genome sequences were detected among the positive RT–qPCR samples. Our identified sequences belonged to the East/Central/South/African (ECSA) genotype, which has been prevalent in Vietnam previously, suggesting CHIKV has been maintained and is endemic in Vietnam. This study demonstrates a high prevalence of CHIKV infection in Vietnam and calls for an annual surveillance program to understand its impact.</jats:p>
収録刊行物
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- Viruses
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Viruses 15 (10), 2065-, 2023-10-08
MDPI AG
