Photocrosslinked Co‐Assembled Amino Acid Nanoparticles for Controlled Chemo/Photothermal Combined Anticancer Therapy

DOI Web Site 参考文献47件
  • Tengfei Wang
    CNRS Immunology Immunopathology and Therapeutic Chemistry UPR 3572 University of Strasbourg ISIS Strasbourg 67000 France
  • Yun Qi
    Graduate School of Advanced Science and Technology Japan Advanced Institute of Science and Technology 1‐1 Asahidai Nomi Ishikawa 923–1292 Japan
  • Eijiro Miyako
    Graduate School of Advanced Science and Technology Japan Advanced Institute of Science and Technology 1‐1 Asahidai Nomi Ishikawa 923–1292 Japan
  • Alberto Bianco
    CNRS Immunology Immunopathology and Therapeutic Chemistry UPR 3572 University of Strasbourg ISIS Strasbourg 67000 France
  • Cécilia Ménard‐Moyon
    CNRS Immunology Immunopathology and Therapeutic Chemistry UPR 3572 University of Strasbourg ISIS Strasbourg 67000 France

書誌事項

公開日
2023-12-28
資源種別
journal article
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/smll.202307337
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Nanostructures formed from the self‐assembly of amino acids are promising materials in many fields, especially for biomedical applications. However, their low stability resulting from the weak noncovalent interactions between the amino acid building blocks limits their use. In this work, nanoparticles co‐assembled by fluorenylmethoxycarbonyl (Fmoc)‐protected tyrosine (Fmoc‐Tyr‐OH) and tryptophan (Fmoc‐Trp‐OH) are crosslinked by ultraviolet (UV) light irradiation. Two methods are investigated to induce the dimerization of tyrosine, irradiating at 254 nm or at 365 nm in the presence of riboflavin as a photo‐initiator. For the crosslinking performed at 254 nm, both Fmoc‐Tyr‐OH and Fmoc‐Trp‐OH generate dimers. In contrast, only Fmoc‐Tyr‐OH participates in the riboflavin‐mediated dimerization under irradiation at 365 nm. The participation of both amino acids in forming the dimers leads to more stable crosslinked nanoparticles, allowing also to perform further chemical modifications for cancer applications. The anticancer drug doxorubicin (Dox) is adsorbed onto the crosslinked nanoparticles, subsequently coated by a tannic acid‐iron complex, endowing the nanoparticles with glutathione‐responsiveness and photothermal properties, allowing to control the release of Dox. A remarkable anticancer efficiency is obtained in vitro and in vivo in tumor‐bearing mice thanks to the combined chemo‐ and photothermal treatment.</jats:p>

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    Small 20 (23), 2023-12-28

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