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- Maki Tsujita
- Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Japan (M.T.).
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- John T. Melchior
- Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington (J.T.M.).
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- Shinji Yokoyama
- Department of Food and Nutritional Sciences, Chubu University, Kasugai, Japan (S.Y.).
書誌事項
- 公開日
- 2024-05
- 資源種別
- journal article
- DOI
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- 10.1161/atvbaha.123.318284
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:p>The brain is the most lipid-rich organ in the body, and the intricate interplay between lipid metabolism and pathologies associated with neurodegenerative disorders is being increasingly recognized. The brain is bathed in cerebrospinal fluid (CSF), which, like plasma, contains lipid-protein complexes called lipoproteins that are responsible for extracellular lipid transport. Multiple CSF lipoprotein populations exist, some of which are produced de novo in the central nervous system and others that appear to be generated from protein constituents that are produced in the periphery. These CSF lipoproteins are thought to play key roles in maintaining lipid homeostasis in the central nervous system, while little else is known due to their limited accessibility and their low abundance in CSF. Recent work has provided new insights into the compositional complexity of CSF lipoprotein families and their metabolism in cerebral circulation. The purpose of this review is to summarize our current state of knowledge on the composition, origin, and metabolism of CSF lipoproteins.</jats:p>
収録刊行物
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- Arteriosclerosis, Thrombosis, and Vascular Biology
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Arteriosclerosis, Thrombosis, and Vascular Biology 44 (5), 1042-1052, 2024-05
Ovid Technologies (Wolters Kluwer Health)
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詳細情報 詳細情報について
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- CRID
- 1360021390768013440
-
- ISSN
- 15244636
- 10795642
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- 資料種別
- journal article
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- データソース種別
-
- Crossref
- KAKEN
- OpenAIRE
