3D Bioprinting tissue analogs: Current development and translational implications

  • Suihong Liu
    Centre for Translational Bone, Joint and Soft Tissue Research, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
  • Lijia Cheng
    School of Basic Medical Sciences, Clinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China
  • Yakui Liu
    Centre for Translational Bone, Joint and Soft Tissue Research, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
  • Haiguang Zhang
    Rapid Manufacturing Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, China
  • Yongteng Song
    Rapid Manufacturing Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, China
  • Jeong-Hui Park
    Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, South Korea
  • Khandmaa Dashnyam
    Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, South Korea
  • Jung-Hwan Lee
    Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, South Korea
  • Fouad Al-Hakim Khalak
    NanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain
  • Oliver Riester
    Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Strasse 17, Villingen-Schwenningen, Germany
  • Zheng Shi
    School of Basic Medical Sciences, Clinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China
  • Serge Ostrovidov
    Department of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
  • Hirokazu Kaji
    Department of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
  • Hans-Peter Deigner
    Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Strasse 17, Villingen-Schwenningen, Germany
  • José Luis Pedraz
    NanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain
  • Jonathan C Knowles
    Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, South Korea
  • Qingxi Hu
    Rapid Manufacturing Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, China
  • Hae-Won Kim
    Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, South Korea
  • Murugan Ramalingam
    School of Basic Medical Sciences, Clinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China

書誌事項

公開日
2023-01
資源種別
journal article
権利情報
  • https://creativecommons.org/licenses/by-nc/4.0/
DOI
  • 10.1177/20417314231187113
公開者
SAGE Publications

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説明

<jats:p> Three-dimensional (3D) bioprinting is a promising and rapidly evolving technology in the field of additive manufacturing. It enables the fabrication of living cellular constructs with complex architectures that are suitable for various biomedical applications, such as tissue engineering, disease modeling, drug screening, and precision regenerative medicine. The ultimate goal of bioprinting is to produce stable, anatomically-shaped, human-scale functional organs or tissue substitutes that can be implanted. Although various bioprinting techniques have emerged to develop customized tissue-engineering substitutes over the past decade, several challenges remain in fabricating volumetric tissue constructs with complex shapes and sizes and translating the printed products into clinical practice. Thus, it is crucial to develop a successful strategy for translating research outputs into clinical practice to address the current organ and tissue crises and improve patients’ quality of life. This review article discusses the challenges of the existing bioprinting processes in preparing clinically relevant tissue substitutes. It further reviews various strategies and technical feasibility to overcome the challenges that limit the fabrication of volumetric biological constructs and their translational implications. Additionally, the article highlights exciting technological advances in the 3D bioprinting of anatomically shaped tissue substitutes and suggests future research and development directions. This review aims to provide readers with insight into the state-of-the-art 3D bioprinting techniques as powerful tools in engineering functional tissues and organs. </jats:p>

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