Runt-related Transcription Factors and Gene Regulatory Mechanisms in Skeletal Development and Diseases
書誌事項
- 公開日
- 2023-07-12
- 資源種別
- journal article
- 権利情報
-
- https://creativecommons.org/licenses/by/4.0
- https://creativecommons.org/licenses/by/4.0
- DOI
-
- 10.1007/s11914-023-00808-4
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose of Review</jats:title> <jats:p>Runt-related transcription factors (RUNX) play critical roles in skeletal development, metabolism, and diseases. In mammals, three RUNX members, namely RUNX1, RUNX2, and RUNX3, play distinct and redundant roles, although RUNX2 is a dominant factor in skeletal development and several skeletal diseases. This review is to provide an overview of the current understanding of RUNX-mediated transcriptional regulation in different skeletal cell types.</jats:p> </jats:sec><jats:sec> <jats:title>Recent Findings</jats:title> <jats:p>Advances in chromatin immunoprecipitation and next-generation sequencing (ChIP-seq) have revealed genome-wide RUNX-mediated gene regulatory mechanisms, including their association with cis-regulatory elements and putative target genes. Further studies with genome-wide analysis and biochemical assays have shed light on RUNX-mediated pioneering action and involvements of RUNX2 in lipid–lipid phase separation.</jats:p> </jats:sec><jats:sec> <jats:title>Summary</jats:title> <jats:p>Emerging multi-layered mechanisms of RUNX-mediated gene regulations help us better understanding of skeletal development and diseases, which also provides clues to think how genome-wide studies can help develop therapeutic strategies for skeletal diseases.</jats:p> </jats:sec>
収録刊行物
-
- Current Osteoporosis Reports
-
Current Osteoporosis Reports 21 (5), 485-492, 2023-07-12
Springer Science and Business Media LLC
