書誌事項
- 公開日
- 2023-12-20
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1371/journal.pone.0296037
- 公開者
- Public Library of Science (PLoS)
説明
<jats:p>Recent evidence suggests a crucial role of the gut microbiota in the pathogenesis of anorexia nervosa (AN). In this study, we carried out a series of multiple analyses of the gut microbiota of hospitalized individuals with AN over three months using 16S or 23S rRNA-targeted reverse transcription–quantitative polymerase chain reaction (PCR) technology (YIF-SCAN<jats:sup>®</jats:sup>), which is highly sensitive and enables the precise quantification of viable microorganisms. Despite the weight gain and improvements in psychological features observed during treatment, individuals with AN exhibited persistent gut microbial dysbiosis over the three-month duration. Principal component analysis further underscored the distinct microbial profile of individuals with AN, compared with that of age-matched healthy women at all time points. Regarding the kinetics of bacterial detection, the detection rate of <jats:italic>Lactiplantibacillus</jats:italic> spp. significantly increased after inpatient treatment. Additionally, the elevation in the <jats:italic>Bifidobacterium</jats:italic> counts during inpatient treatment was significantly correlated with the subsequent body weight gain after one year. Collectively, these findings suggest that gut dysbiosis in individuals with AN may not be easily restored solely through weight gain, highlighting the potential of therapeutic interventions targeting microbiota via dietary modifications or live biotherapeutics.</jats:p>
収録刊行物
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- PLOS ONE
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PLOS ONE 18 (12), e0296037-, 2023-12-20
Public Library of Science (PLoS)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360021391865814144
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- ISSN
- 19326203
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
