Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities
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- Noe Kawade
- Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine Nagoya University Japan
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- Koji Yamanaka
- Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine Nagoya University Japan
書誌事項
- 公開日
- 2023-06-26
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- http://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1002/2211-5463.13661
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Alzheimer's disease (AD) is the most common cause of dementia. A genome‐wide association study has shown that several AD risk genes are involved in lipid metabolism. Additionally, epidemiological studies have indicated that the levels of several lipid species are altered in the AD brain. Therefore, lipid metabolism is likely changed in the AD brain, and these alterations might be associated with an exacerbation of AD pathology. Oligodendrocytes are glial cells that produce the myelin sheath, which is a lipid‐rich insulator. Dysfunctions of the myelin sheath have been linked to white matter abnormalities observed in the AD brain. Here, we review the lipid composition and metabolism in the brain and myelin and the association between lipidic alterations and AD pathology. We also present the abnormalities in oligodendrocyte lineage cells and white matter observed in AD. Additionally, we discuss metabolic disorders, including obesity, as AD risk factors and the effects of obesity and dietary intake of lipids on the brain.</jats:p>
収録刊行物
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- FEBS Open Bio
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FEBS Open Bio 14 (2), 194-216, 2023-06-26
Wiley
