Role of Extracellular Vesicles in Absorption and Functional Mechanisms of Quercetin
-
- Akari Ishisaka
- Department of Food Science and Nutrition School of Human Science and Environment University of Hyogo 1‐1‐12, Shinzaike‐Honcho Himeji Hyogo 670‐0092 Japan
-
- Ryosuke Sugimoto
- Department of Food Science and Nutrition School of Human Science and Environment University of Hyogo 1‐1‐12, Shinzaike‐Honcho Himeji Hyogo 670‐0092 Japan
-
- Haruka Marumo
- Department of Food Science and Nutrition School of Human Science and Environment University of Hyogo 1‐1‐12, Shinzaike‐Honcho Himeji Hyogo 670‐0092 Japan
-
- Tomoki Doi
- Department of Food Science and Nutrition School of Human Science and Environment University of Hyogo 1‐1‐12, Shinzaike‐Honcho Himeji Hyogo 670‐0092 Japan
-
- Kaede Hamada
- Department of Food Science and Nutrition School of Human Science and Environment University of Hyogo 1‐1‐12, Shinzaike‐Honcho Himeji Hyogo 670‐0092 Japan
-
- Misa Fujimoto
- Department of Food Science and Nutrition School of Human Science and Environment University of Hyogo 1‐1‐12, Shinzaike‐Honcho Himeji Hyogo 670‐0092 Japan
-
- Nao Fujiwara
- Department of Food Science and Nutrition School of Human Science and Environment University of Hyogo 1‐1‐12, Shinzaike‐Honcho Himeji Hyogo 670‐0092 Japan
-
- Masao Yamasaki
- Department of Biochemistry and Applied Biosciences Faculty of Agriculture University of Miyazaki Gakuen‐kibanadai‐nishi‐1‐1 Miyazaki 889‐2192 Japan
-
- Akira Murakami
- Department of Food Science and Nutrition School of Human Science and Environment University of Hyogo 1‐1‐12, Shinzaike‐Honcho Himeji Hyogo 670‐0092 Japan
書誌事項
- 公開日
- 2023-09-06
- 資源種別
- journal article
- 権利情報
-
- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
-
- 10.1002/mnfr.202300225
- 公開者
- Wiley
この論文をさがす
説明
<jats:sec><jats:title>Scope</jats:title><jats:p>Quercetin (QUE), a phytochemical found in various plant foods, has been shown to have a variety of physiological activities in vivo, though biological sites where it has activities and the mechanisms of transport have not been fully elucidated.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>In the present study, intracellular uptake of QUE into HT‐29 human colon adenocarcinoma cells is found to result in spontaneous release of extracellular vesicles (EVs), which are subsequently embedded with QUE. In addition, QUE‐embedded EVs are detected in serum of QUE‐administered Sprague‐Dawley rats. Interestingly, the rate of cellular uptake of QUE‐encapsulated EVs (EV‐QUE) into RAW264.7 macrophages is markedly higher than that of free QUE. Moreover, EV‐QUE suppresses lipopolysaccharide (LPS)‐induced nitric oxide at a lower concentration than free QUE.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The present findings suggest that QUE may be embedded in EVs in the gastrointestinal tract, then become absorbed and enter the bloodstream to exhibit biological activities.</jats:p></jats:sec>
収録刊行物
-
- Molecular Nutrition & Food Research
-
Molecular Nutrition & Food Research 67 (21), e2300225-, 2023-09-06
Wiley
