Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein

DOI Web Site 参考文献22件 オープンアクセス
  • Hendris Wongso
    School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia
  • Maiko Ono
    Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
  • Tomoteru Yamasaki
    Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
  • Katsushi Kumata
    Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
  • Makoto Higuchi
    Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
  • Ming-Rong Zhang
    Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
  • Michael J. Fulham
    Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
  • Andrew Katsifis
    Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
  • Paul A. Keller
    School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia

書誌事項

公開日
2023
資源種別
journal article
権利情報
  • http://rsc.li/journals-terms-of-use
DOI
  • 10.1039/d2md00358a
公開者
Royal Society of Chemistry (RSC)

説明

<jats:p>A series of tau ligands was synthesized replacing the photoisomerisable <jats:italic>trans</jats:italic>-diene bridge of PBB3 with 1,2,3-triazole, amide, and ester moieties. Several ligands were able to visualise Aβ plaques and neurofibrillary tangles in Alzheimer's disease.</jats:p>

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