Tracing the evolutionary history of blood cells to the unicellular ancestor of animals
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- Yosuke Nagahata
- 1Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan
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- Kyoko Masuda
- 1Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan
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- Yuji Nishimura
- 1Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan
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- Tomokatsu Ikawa
- 3Division of Immunology and Allergy, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan
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- Shinpei Kawaoka
- 4Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan
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- Toshio Kitawaki
- 2Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Yasuhito Nannya
- 5Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Seishi Ogawa
- 5Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Hiroshi Suga
- 6Department of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara, Japan
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- Yutaka Satou
- 7Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
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- Akifumi Takaori-Kondo
- 2Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Hiroshi Kawamoto
- 1Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan
書誌事項
- 公開日
- 2022-12-15
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by-nc-nd/4.0/
- DOI
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- 10.1182/blood.2022016286
- 公開者
- American Society of Hematology
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説明
<jats:title>Abstract</jats:title> <jats:p>Blood cells are thought to have emerged as phagocytes in the common ancestor of animals followed by the appearance of novel blood cell lineages such as thrombocytes, erythrocytes, and lymphocytes, during evolution. However, this speculation is not based on genetic evidence and it is still possible to argue that phagocytes in different species have different origins. It also remains to be clarified how the initial blood cells evolved; whether ancient animals have solely developed de novo programs for phagocytes or they have inherited a key program from ancestral unicellular organisms. Here, we traced the evolutionary history of blood cells, and cross-species comparison of gene expression profiles revealed that phagocytes in various animal species and Capsaspora (C.) owczarzaki, a unicellular organism, are transcriptionally similar to each other. We also found that both phagocytes and C. owczarzaki share a common phagocytic program, and that CEBPα is the sole transcription factor highly expressed in both phagocytes and C. owczarzaki. We further showed that the function of CEBPα to drive phagocyte program in nonphagocytic blood cells has been conserved in tunicate, sponge, and C. owczarzaki. We finally showed that, in murine hematopoiesis, repression of CEBPα to maintain nonphagocytic lineages is commonly achieved by polycomb complexes. These findings indicate that the initial blood cells emerged inheriting a unicellular organism program driven by CEBPα and that the program has also been seamlessly inherited in phagocytes of various animal species throughout evolution.</jats:p>
収録刊行物
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- Blood
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Blood 140 (24), 2611-2625, 2022-12-15
American Society of Hematology
