Country-level gender inequality is associated with structural differences in the brains of women and men

  • André Zugman
    Section on Development and Affective Neuroscience (SDAN), Emotion and Development Branch (E & D), National Institute of Mental Health, National Institutes of Health, Bethesda MD 20894
  • Luz María Alliende
    Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile
  • Vicente Medel
    Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago 7941169, Chile
  • Richard A.I. Bethlehem
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, United Kingdom
  • Jakob Seidlitz
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
  • Grace Ringlein
    Section on Development and Affective Neuroscience (SDAN), Emotion and Development Branch (E & D), National Institute of Mental Health, National Institutes of Health, Bethesda MD 20894
  • Celso Arango
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), School of Medicine, Universidad Complutense, Madrid 28009, Spain
  • Aurina Arnatkevičiūtė
    The Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC 3168, Australia
  • Laila Asmal
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7602, South Africa
  • Mark Bellgrove
    The Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC 3168, Australia
  • Vivek Benegal
    Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka 560029, India
  • Miquel Bernardo
    Barcelona Clinic Schizophrenia Unit, Hospital Clínic de Barcelona, Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Institut d’Investigacions Biomèdiques, August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Barcelona 08036, Spain
  • Pablo Billeke
    Laboratorio de Neurociencia Social y Neuromodulación, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del Desarrollo, Santiago 7610658, Chile
  • Jorge Bosch-Bayard
    McGill Centre for Integrative Neuroscience, Ludmer Centre for Neuroinformatics and Mental Health, Montreal Neurological Institute, Montreal, QC H3A 2B4, Canada
  • Rodrigo Bressan
    Interdisciplinary Laboratory in Clinical Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo 04039-032, Brazil
  • Geraldo F. Busatto
    Departamento e Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-903, Brazil
  • Mariana N. Castro
    Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta (INAAC), Fleni-Consejo Nacional de Investigaciones Científicas y Técnicas Neurosciences Institute (INEU), Ciudad Autónoma de Buenos Aires C1428, Argentina
  • Tiffany Chaim-Avancini
    Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina Universidade de São Paulo (HCFMUSP), Faculdade de Medicina Universidade de São Paulo, São Paulo SP 05403-903, Brazil
  • Albert Compte
    Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain
  • Monise Costanzi
    Laboratory of Molecular Psychiatry, Centro de Pesquisa Clínica, Hospital de Clínicas de Porto Alegre, Porto Alegre RS 90035-007, Brazil
  • Leticia Czepielewski
    Laboratory of Molecular Psychiatry, Centro de Pesquisa Clínica, Hospital de Clínicas de Porto Alegre, Porto Alegre RS 90035-007, Brazil
  • Paola Dazzan
    Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  • Camilo de la Fuente-Sandoval
    Laboratory of Experimental Psychiatry, Direction of Research, Instituto Nacional de Neurología y Neurocirugía, Mexico City 14269, Mexico
  • Marta Di Forti
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  • Covadonga M. Díaz-Caneja
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), School of Medicine, Universidad Complutense, Madrid 28009, Spain
  • Ana María Díaz-Zuluaga
    Department of Psychiatry, Faculty of Medicine, University of Antioquia, Medellín 050011, Colombia
  • Stefan Du Plessis
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7602, South Africa
  • Fabio L. S. Duran
    Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina Universidade de São Paulo (HCFMUSP), Faculdade de Medicina Universidade de São Paulo, São Paulo SP 05403-903, Brazil
  • Sol Fittipaldi
    Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago 7941169, Chile
  • Alex Fornito
    The Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC 3168, Australia
  • Nelson B. Freimer
    Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior Los Angeles, University of California Los Angeles (UCLA), Los Angeles, CA 90024
  • Ary Gadelha
    Interdisciplinary Laboratory in Clinical Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo 04039-032, Brazil
  • Clarissa S. Gama
    Laboratory of Molecular Psychiatry, Centro de Pesquisa Clínica, Hospital de Clínicas de Porto Alegre, Porto Alegre RS 90035-007, Brazil
  • Ranjini Garani
    Integrated Program in Neuroscience, McGill University, Montreal, Quebec H3A 1A12B4 Canada
  • Clemente Garcia-Rizo
    Barcelona Clinic Schizophrenia Unit, Hospital Clínic de Barcelona, Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Institut d’Investigacions Biomèdiques, August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Barcelona 08036, Spain
  • Cecilia Gonzalez Campo
    Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires C1033AAJ, Argentina
  • Alfonso Gonzalez-Valderrama
    Early Intervention Program, Instituto Psiquiátrico Dr. J. Horwitz Barak, Santiago 8431621, Chile
  • Salvador Guinjoan
    Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires C1033AAJ, Argentina
  • Bharath Holla
    Department of Integrative Medicine, NIMHANS, Bengaluru, Karnataka 560029, India
  • Agustín Ibañez
    Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago 7941169, Chile
  • Daniza Ivanovic
    Laboratorio de Neurociencia Social y Neuromodulación, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del Desarrollo, Santiago 7610658, Chile
  • Andrea Jackowski
    Department of Psychiatry, Universidade Federal de São Paulo, São Paulo 04038-000, Brazil
  • Pablo Leon-Ortiz
    Laboratory of Experimental Psychiatry, Direction of Research, Instituto Nacional de Neurología y Neurocirugía, Mexico City 14269, Mexico
  • Christine Lochner
    South African Medical Research Council (SA MRC) Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch 7505, South Africa
  • Carlos López-Jaramillo
    Department of Psychiatry, Faculty of Medicine, University of Antioquia, Medellín 050011, Colombia
  • Hilmar Luckhoff
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7602, South Africa
  • Raffael Massuda
    Department of Psychiatry, Universidade Federal do Paraná (UFPR), Curitiba PR 80060-000, Brazil
  • Philip McGuire
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, United Kingdom
  • Jun Miyata
    Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
  • Romina Mizrahi
    Integrated Program in Neuroscience, McGill University, Montreal, Quebec H3A 1A12B4 Canada
  • Robin Murray
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  • Aysegul Ozerdem
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota MN 55905
  • Pedro M. Pan
    Interdisciplinary Laboratory in Clinical Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo 04039-032, Brazil
  • Mara Parellada
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), School of Medicine, Universidad Complutense, Madrid 28009, Spain
  • Lebogan Phahladira
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7602, South Africa
  • Juan P. Ramirez-Mahaluf
    Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile
  • Ramiro Reckziegel
    Laboratory of Molecular Psychiatry, Centro de Pesquisa Clínica, Hospital de Clínicas de Porto Alegre, Porto Alegre RS 90035-007, Brazil
  • Tiago Reis Marques
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  • Francisco Reyes-Madrigal
    Laboratory of Experimental Psychiatry, Direction of Research, Instituto Nacional de Neurología y Neurocirugía, Mexico City 14269, Mexico
  • Annerine Roos
    South African Medical Research Council (SA MRC) Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town 7925, South Africa
  • Pedro Rosa
    Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina Universidade de São Paulo (HCFMUSP), Faculdade de Medicina Universidade de São Paulo, São Paulo SP 05403-903, Brazil
  • Giovanni Salum
    Department of Psychiatry, Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035903, Brazil
  • Freda Scheffler
    South African Medical Research Council (SA MRC) Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town 7925, South Africa
  • Gunter Schumann
    Centre for Population Neuroscience and Stratified Medicine (PONS), Institute for Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai 200433, China
  • Mauricio Serpa
    Departamento e Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-903, Brazil
  • Dan J. Stein
    South African Medical Research Council (SA MRC) Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town 7925, South Africa
  • Angeles Tepper
    Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile
  • Jeggan Tiego
    The Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC 3168, Australia
  • Tsukasa Ueno
    Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
  • Juan Undurraga
    Early Intervention Program, Instituto Psiquiátrico Dr. J. Horwitz Barak, Santiago 8431621, Chile
  • Eduardo A. Undurraga
    Escuela de Gobierno, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
  • Pedro Valdes-Sosa
    The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu 610054, China
  • Isabel Valli
    Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain
  • Mirta Villarreal
    Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta (INAAC), Fleni-Consejo Nacional de Investigaciones Científicas y Técnicas Neurosciences Institute (INEU), Ciudad Autónoma de Buenos Aires C1428, Argentina
  • Toby T. Winton-Brown
    Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia
  • Nefize Yalin
    Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  • Francisco Zamorano
    Unidad de Imágenes Cuantitativas Avanzadas, Departamento de Imágenes, Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago 7650568, Chile
  • Marcus V. Zanetti
    Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina Universidade de São Paulo (HCFMUSP), Faculdade de Medicina Universidade de São Paulo, São Paulo SP 05403-903, Brazil
  • Anderson M. Winkler
    Department of Human Genetics, University of Texas Rio Grande Valley, Brownsville, Texas TX 78520
  • Daniel S. Pine
    Section on Development and Affective Neuroscience (SDAN), Emotion and Development Branch (E & D), National Institute of Mental Health, National Institutes of Health, Bethesda MD 20894
  • Sara Evans-Lacko
    Care Policy and Evaluation Centre, School of Economics and Political Science, London WC2A 2AE, United Kingdom
  • Nicolas A. Crossley
    Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile

書誌事項

公開日
2023-05-08
権利情報
  • https://creativecommons.org/licenses/by/4.0/
DOI
  • 10.1073/pnas.2218782120
公開者
Proceedings of the National Academy of Sciences

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説明

<jats:p>Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse socio-environmental experiences. Therefore, unequal exposure to harsher conditions for women compared to men in gender-unequal countries might be reflected in differences in their brain structure, and this could be the neural mechanism partly explaining women’s worse outcomes in gender-unequal countries. We examined this through a random-effects meta-analysis on cortical thickness and surface area differences between adult healthy men and women, including a meta-regression in which country-level gender inequality acted as an explanatory variable for the observed differences. A total of 139 samples from 29 different countries, totaling 7,876 MRI scans, were included. Thickness of the right hemisphere, and particularly the right caudal anterior cingulate, right medial orbitofrontal, and left lateral occipital cortex, presented no differences or even thicker regional cortices in women compared to men in gender-equal countries, reversing to thinner cortices in countries with greater gender inequality. These results point to the potentially hazardous effect of gender inequality on women’s brains and provide initial evidence for neuroscience-informed policies for gender equality.</jats:p>

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