The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration
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- Darren Chen Pei Wong
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Catherine Qiurong Pan
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Shi Yin Er
- Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, Singapore 117558
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- T. Thivakar
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Tan Zi Yi Rachel
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Sock Hong Seah
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Pei Jou Chua
- Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, Singapore 117594
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- Tingting Jiang
- Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, Singapore 117558
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- Ti Weng Chew
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Parthiv Kant Chaudhuri
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Somsubhro Mukherjee
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Agus Salim
- Melbourne School of Population and Global Health and School of Mathematics and Statistics, The University of Melbourne, Melbourne, Victoria 3052, Australia
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- Thike Aye Aye
- Department of Pathology, Singapore General Hospital, Singapore 169856
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- Cheng Gee Koh
- Division of Molecular Genetics & Cell Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551
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- Chwee Teck Lim
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Puay Hoon Tan
- Department of Pathology, Singapore General Hospital, Singapore 169856
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- Boon Huat Bay
- Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, Singapore 117594
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- Anne J. Ridley
- School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, United Kingdom
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- Boon Chuan Low
- Mechanobiology Institute, National University of Singapore, Singapore 117411
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- Alpha Yap
- editor
書誌事項
- 公開日
- 2023-03-01
- DOI
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- 10.1091/mbc.e21-03-0099
- 公開者
- American Society for Cell Biology (ASCB)
この論文をさがす
説明
<jats:p> How the activities of Rho and Rac are coordinated through their GEF and GAP remains unclear. The prometastatic RhoGAP, BPGAP1, recruits the RacGEF Vav1 to activate Rac1 while it down-regulates the local RhoA activity that in turns influences Rac1 activation by Vav1. BPGAP1 acts as a scaffold to synchronize Rho and Rac signaling in cell motility. </jats:p>
収録刊行物
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- Molecular Biology of the Cell
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Molecular Biology of the Cell 34 (3), 2023-03-01
American Society for Cell Biology (ASCB)