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- Christian E. Zimmerli
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
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- Matteo Allegretti
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
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- Vasileios Rantos
- Centre for Structural Systems Biology (CSSB), 22607 Hamburg, Germany.
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- Sara K. Goetz
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
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- Agnieszka Obarska-Kosinska
- Department of Molecular Sociology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
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- Ievgeniia Zagoriy
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
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- Aliaksandr Halavatyi
- Advanced Light Microscopy Facility, EMBL, 69117 Heidelberg, Germany.
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- Gerhard Hummer
- Department of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
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- Julia Mahamid
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
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- Jan Kosinski
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
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- Martin Beck
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
書誌事項
- 公開日
- 2021-12-10
- DOI
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- 10.1126/science.abd9776
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Mechanosensitive nuclear pores</jats:title> <jats:p> The nucleus of eukaryotic cells is enclosed by the nuclear envelope, a double membrane punctuated with nuclear pore complexes (NPCs). These giant channels in the nuclear envelope mediate nucleocytoplasmic exchange. Zimmerli <jats:italic>et al</jats:italic> . show that the mechanical status of the nuclear membranes controls their nuclear pore diameter. Pulling forces imposed through nuclear membranes lead to stretching of NPCs and dilation of their diameter, whereas relief of such forces causes NPC constriction. Thus, the control of nuclear size and shape is functionally linked with NPC conformation and nucleocytoplasmic transport activity. —SMH </jats:p>
収録刊行物
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- Science
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Science 374 (6573), eabd9776-, 2021-12-10
American Association for the Advancement of Science (AAAS)