Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application

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  • Wenzhao Wang
    Orthopedic Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610041 , China
  • Boqing Zhang
    National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064 , China
  • Lihong Zhao
    Orthopedic Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610041 , China
  • Mingxin Li
    Orthopedic Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610041 , China
  • Yanlong Han
    Department of Orthopedics, The People’s Hospital of Xinjiang Uygur Autonomous Region , Urumqi 830001 , China
  • Li Wang
    Department of Orthopedics, The People’s Hospital of Xinjiang Uygur Autonomous Region , Urumqi 830001 , China
  • Zhengdong Zhang
    Orthopedic Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610041 , China
  • Jun Li
    Orthopedic Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610041 , China
  • Changchun Zhou
    National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064 , China
  • Lei Liu
    Orthopedic Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610041 , China

Description

<jats:title>Abstract</jats:title> <jats:p>Repair of critical bone defects is a challenge in the orthopedic clinic. 3D printing is an advanced personalized manufacturing technology that can accurately shape internal structures and external contours. In this study, the composite scaffolds of polylactic acid (PLA) and nano-hydroxyapatite (n-HA) were manufactured by the fused deposition modeling (FDM) technique. Equal mass PLA and n-HA were uniformly mixed to simulate the organic and inorganic phases of natural bone. The suitability of the composite scaffolds was evaluated by material characterization, mechanical property, and <jats:italic>in vitro</jats:italic> biocompatibility, and the osteogenesis induction <jats:italic>in vitro</jats:italic> was further tested. Finally, the printed scaffold was implanted into the rabbit femoral defect model to evaluate the osteogenic ability <jats:italic>in vivo</jats:italic>. The results showed that the composite scaffold had sufficient mechanical strength, appropriate pore size, and biocompatibility. Most importantly, the osteogenic induction performance of the composite scaffold was significantly better than that of the pure PLA scaffold. In conclusion, the PLA/n-HA scaffold is a promising composite biomaterial for bone defect repair and has excellent clinical transformation potential.</jats:p>

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