Encapsulation of Drug Molecules by Cucurbiturils: Effects on their Chemical Properties in Aqueous Solution
書誌事項
- 公開日
- 2011-04-15
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/ijch.201100040
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The effects of the encapsulation of drugs and other molecules of biomedical interest by cucurbit[<jats:italic>n</jats:italic>]uril (<jats:italic>n</jats:italic>=5–8, 10) host molecules on the chemical properties of the drugs in aqueous solution are reviewed. The cucurbituril complexation of drug molecules has been shown to generally increase the guests’ p<jats:italic>K</jats:italic><jats:sub>a</jats:sub>values through preferential inclusion of the protonated species, modulate other equilibria involving the guest, improve the solubility in aqueous solution, reduce the toxicity and other side effects, as well as enhance the stability and targeted delivery of the drug molecule. These benefits have led to an increasing interest in the applications of cucurbit[<jats:italic>n</jats:italic>]urils in novel drug formulations.</jats:p>
収録刊行物
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- Israel Journal of Chemistry
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Israel Journal of Chemistry 51 (5-6), 600-615, 2011-04-15
Wiley