Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma
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- Nakhle S. Saba
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- Delong Liu
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- Sarah E. M. Herman
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- Chingiz Underbayev
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- Xin Tian
- Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- David Behrend
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- Marc A. Weniger
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- Martin Skarzynski
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- Jennifer Gyamfi
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
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- Lorena Fontan
- Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY;
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- Ari Melnick
- Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY;
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- Cliona Grant
- Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;
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- Mark Roschewski
- Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;
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- Alba Navarro
- Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain; and
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- Sílvia Beà
- Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain; and
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- Stefania Pittaluga
- Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
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- Kieron Dunleavy
- Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;
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- Wyndham H. Wilson
- Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;
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- Adrian Wiestner
- Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
書誌事項
- 公開日
- 2016-07-07
- DOI
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- 10.1182/blood-2015-11-681460
- 公開者
- American Society of Hematology
この論文をさがす
説明
<jats:title>Key Points</jats:title> <jats:p>Activation of BCR and canonical NF-κB signaling in the lymph node correlates with survival in MCL. Mutations and polymorphisms in BCR and NF-κB pathways may confer cell autonomous signaling and affect response to ibrutinib.</jats:p>
収録刊行物
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- Blood
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Blood 128 (1), 82-92, 2016-07-07
American Society of Hematology