TROPION-Breast01: Datopotamab deruxtecan vs chemotherapy in pre-treated inoperable or metastatic HR+/HER2– breast cancer

  • Aditya Bardia
    Massachusetts General Hospital Cancer Center, Boston, MA, USA
  • Komal Jhaveri
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
  • Kevin Kalinsky
    Winship Cancer Institute at Emory University, Atlanta, GA, USA
  • Sonia Pernas
    Institut Català d’Oncologia, IDIBELL, L’Hospitalet, Barcelona, Spain
  • Junji Tsurutani
    Showa University Hospital, Tokyo, Japan
  • Binghe Xu
    National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • Erika Hamilton
    Sarah Cannon Research Institute / Tennessee Oncology, Nashville, TN, USA
  • Seock-Ah Im
    Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul National University, Seoul, Republic of Korea
  • Zbigniew Nowecki
    Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
  • Joohyuk Sohn
    Yonsei University College of Medicine, Seoul, Republic of Korea
  • Michelino De Laurentiis
    Istituto Nazionale Tumori Napoli IRCCS “Fondazione Pascale”, Napoli, Italy
  • Noelia Martínez Jañez
    Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
  • Barbara Adamo
    August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain
  • Keun Seok Lee
    Center for Breast Cancer, National Cancer Center, Goyang, Republic of Korea
  • Kyung Hae Jung
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
  • Gábor Rubovszky
    National Institute of Oncology, Budapest, Hungary
  • Ling-Ming Tseng
    Comprehensive Breast Health Center, Taipei Veterans General Hospital, Taipei, Taiwan
  • Yen-Shen Lu
    National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
  • Yuan Yuan
    Formerly City of Hope Comprehensive Cancer Center, Duarte, CA, USA; Currently: Cedars-Sinai Cancer Center, Los Angeles, CA, USA
  • Micah J Maxwell
    AstraZeneca, Gaithersburg, MD, USA
  • Vincent Haddad
    AstraZeneca, Cambridge, UK
  • Sabrina S Khan
    AstraZeneca, Gaithersburg, MD, USA
  • Hope S Rugo
    University of California San Francisco Comprehensive Cancer Center, San Francisco, CA, USA
  • Barbara Pistilli
    Gustave Roussy Cancer Center, Villejuif, France

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Description

Improving the prognosis for patients with metastatic HR+/HER2- breast cancer remains an unmet need. Patients with tumors that have progressed on endocrine therapy and/or are not eligible for endocrine therapy had limited treatment options beyond chemotherapy. Antibody-drug conjugates are a novel and promising treatment class in this setting. Datopotamab deruxtecan (Dato-DXd) consists of a TROP2-directed humanized IgG1 monoclonal antibody attachedAntibody-drug conjugates are a type of drug with two parts: an antibody that directs the drug to the cancer cells and a cancer-cell killing toxic payload. By binding to cancer cells before releasing the payload, treatment is directed to the site of action so there are fewer side effects in the rest of the body. Datopotamab deruxtecan (Dato-DXd) is an antibody-drug conjugates made up of datopotamab (antibody) and DXd (payload) which are joined together

Journal

  • Future Oncology

    Future Oncology 20 (8), 423-436, 2023-06-30

    Informa UK Limited

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