Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
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- Luisina Ongaro
- Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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- Xiang Zhou
- Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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- Ying Wang
- Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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- Hailey Schultz
- Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
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- Ziyue Zhou
- Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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- Evan R. S. Buddle
- Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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- Emilie Brûlé
- Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
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- Yeu-Farn Lin
- Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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- Gauthier Schang
- Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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- Adam Hagg
- School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.
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- Roselyne Castonguay
- Discovery Group, Acceleron Pharma Inc., Rahway, NJ, USA.
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- Yewei Liu
- The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
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- Gloria H. Su
- Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
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- Nabil G. Seidah
- Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM)–University of Montreal, Montreal, Quebec, Canada.
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- Kevin C. Ray
- Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
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- Seth J. Karp
- Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
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- Ulrich Boehm
- Department of Pharmacology and Toxicology, University of Saarland School of Medicine, Homburg, Germany.
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- Frederique Ruf-Zamojski
- Cedars-Sinai Medical Center, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Los Angeles, CA, USA.
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- Stuart C. Sealfon
- Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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- Kelly L. Walton
- School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.
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- Se-Jin Lee
- The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
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- Daniel J. Bernard
- Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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説明
<jats:p>Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor–β family, the activins. Our results both challenge activin’s eponymous role in FSH synthesis and establish an unexpected endocrine axis between skeletal muscle and the pituitary gland. Our data also suggest that efforts to antagonize myostatin to increase muscle mass may have unintended consequences on fertility.</jats:p>
収録刊行物
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- Science
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Science 387 (6731), 329-336, 2025-01-17
American Association for the Advancement of Science (AAAS)