Clinical results of definitive chemoradiotherapy for cervical esophageal cancer: Comparison of failure pattern and toxicities between intensity‐modulated radiotherapy and 3‐dimensional conformal radiotherapy
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- Makoto Ito
- Department of Radiation Oncology Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Takeshi Kodaira
- Department of Radiation Oncology Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Hiroyuki Tachibana
- Department of Radiation Oncology Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Natsuo Tomita
- Department of Radiation Oncology Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Chiyoko Makita
- Department of Radiation Oncology Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Yutaro Koide
- Department of Radiation Oncology Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Daiki Kato
- Department of Radiation Oncology Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Tetsuya Abe
- Department of Gastroenterological Surgery Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Kei Muro
- Department of Clinical Oncology Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Masahiro Tajika
- Department of Endoscopy Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Yasumasa Niwa
- Department of Endoscopy Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
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- Yasuhisa Hasegawa
- Department of Head and Neck Surgery Aichi Cancer Center Hospital Chikusa‐ku Nagoya Japan
抄録
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The efficacy of intensity‐modulated radiotherapy (IMRT) for cervical esophageal cancer has not been determined.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Eighty patients with cervical esophageal cancer treated with definitive chemoradiotherapy from 2002 to 2014 were analyzed. Overall survival (OS), failure patterns, and toxicity incidence were compared between the IMRT (N = 32) and 3D conformal radiotherapy (RT; N = 48) groups.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The median follow‐up was 35.9 months. The 3‐year OS of the IMRT, 3D conformal RT, and total groups was 81.6%, 57.2%, and 66.6%, respectively. Pulmonary toxicity was not observed with IMRT. Six of 62 cases (9.6%) with nodal involvement developed upper cervical node recurrence outside the prophylactic region. Ten patients in the IMRT group were salvaged, and 60% survived without recurrence; 20% of the 3D conformal RT group was salvaged.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The IMRT group was comparable with 3D conformal RT group, with a better salvage rate. We recommend extended cervical irradiation for nodal involvement.</jats:p></jats:sec>
収録刊行物
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- Head & Neck
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Head & Neck 39 (12), 2406-2415, 2017-09-27
Wiley
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360283689530746368
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- ISSN
- 10970347
- 10433074
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- データソース種別
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- Crossref
- KAKEN