Concise Syntheses of Dictyodendrins A and F by a Sequential C–H Functionalization Strategy
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- Kathryn M. Chepiga
- Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States
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- Huw M. L. Davies
- Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States
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説明
Syntheses of dictyodendrins A and F have been achieved using a sequential C-H functionalization strategy. The N-alkylpyrrole core is fully functionalized by means of a rhodium(I)-catalyzed C-H arylation at the C3-position, a rhodium(II)-catalyzed double C-H insertion at the C2- and C5-positions, and a Suzuki-Miyaura cross-coupling reaction at the C4-position. The syntheses of dictyodendrins A and F were completed by formal 6π-electrocyclization to generate the pyrrolo[2,3-c]carbazole core of the natural products.
収録刊行物
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- Journal of the American Chemical Society
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Journal of the American Chemical Society 137 (2), 644-647, 2015-01-06
American Chemical Society (ACS)
