Src controls tumorigenesis via JNK‐dependent regulation of the Hippo pathway in <i>Drosophila</i>

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  • Masato Enomoto
    Division of Genetics, Kobe University Graduate School of Medicine 7‐5‐1 Kusunoki‐cho Chuo‐ku Kobe 650‐0017
  • Tatsushi Igaki
    Division of Genetics, Kobe University Graduate School of Medicine 7‐5‐1 Kusunoki‐cho Chuo‐ku Kobe 650‐0017

説明

<jats:p>Cell–cell interactions within the tumour microenvironment have crucial roles in epithelial tumorigenesis. Using <jats:italic>Drosophila</jats:italic> genetics, we show that the oncoprotein Src controls tumour microenvironment by Jun N‐terminal kinase (JNK)‐dependent regulation of the Hippo pathway. Clones of cells with elevated Src expression activate the Rac‐Diaphanous and Ras‐mitogen‐activated protein kinase (MAPK) pathways, which cooperatively induce F‐actin accumulation, thereby leading to activation of the Hippo pathway effector Yorkie (Yki). Simultaneously, Src activates the JNK pathway, which antagonizes the autonomous Yki activity and causes propagation of Yki activity to neighbouring cells, resulting in the overgrowth of surrounding tissue. Our data provide a mechanism to explain how oncogenic mutations regulate tumour microenvironment through cell–cell communication.</jats:p>

収録刊行物

  • EMBO reports

    EMBO reports 14 (1), 65-72, 2012-11-30

    Springer Science and Business Media LLC

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