Dynamic regulation of innate immune responses in <i>Drosophila</i> by Senju-mediated glycosylation

  • Miki Yamamoto-Hino
    Department of Life Science, Rikkyo University, Tokyo 171-8501, Japan;
  • Masatoshi Muraoka
    Stem Cell Project Group, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;
  • Shu Kondo
    Invertebrate Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima 411-8540, Japan; and
  • Ryu Ueda
    Invertebrate Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima 411-8540, Japan; and
  • Hideyuki Okano
    Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan
  • Satoshi Goto
    Department of Life Science, Rikkyo University, Tokyo 171-8501, Japan;

Abstract

<jats:title>Significance</jats:title> <jats:p>The innate immune system is the first line of defense against invading pathogens. Activation of the innate immune response by infection and suppression during steady state are stringently controlled to eliminate pathogens and prevent inflammation. We found that host glycosylation plays an important role in the activation of immune responses and in maintaining innate immune homeostasis. In the steady state, a high amount of galactose-containing glycan suppresses undesirable activation of the immune response; however, activation of immune responses leads to reduced levels of galactose-containing glycan, which is needed for raising immune responses to an adequate level. Our finding suggests a novel mechanism for the regulation of innate immune quiescence and activation via changes in glycosylation status.</jats:p>

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