Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex
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- Hirobumi Tada
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Tomoyuki Miyazaki
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Kiwamu Takemoto
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Kenkichi Takase
- Laboratory of Psychology, Jichi Medical University, Tochigi 329-0498, Japan;
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- Susumu Jitsuki
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Waki Nakajima
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Mayu Koide
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Naoko Yamamoto
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Kasane Komiya
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Kumiko Suyama
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Akane Sano
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
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- Akiko Taguchi
- Department of Integrative Aging Neuroscience, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan
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- Takuya Takahashi
- Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;
Description
<jats:title>Significance</jats:title> <jats:p>Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. In a rat model of neonatal isolation, we examined social dominance in juveniles. We further investigated the relationship between actin dynamics and glutamate synaptic AMPA receptor delivery in spines of the medial prefrontal cortex (mPFC) of isolated animals. Here, we report that neonatal isolation alters spines in the mPFC by reducing actin dynamics, leading to the decrease of synaptic AMPA receptor delivery and altered social behavior later in life. Our study provides molecular and cellular mechanisms underlying the influence of social separation early in life on later social behaviors.</jats:p>
Journal
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 113 (45), E7097-, 2016-10-25
Proceedings of the National Academy of Sciences