Suppression of <scp>DELLA</scp> signaling induces procambial cell formation in culture

  • Kyoko Yamazaki
    Department of Biological Sciences Graduate School of Science the University of Tokyo 7‐3‐1 Hongo, Bunkyo‐ku Tokyo 113‐0033 Japan
  • Yuki Kondo
    Department of Biological Sciences Graduate School of Science the University of Tokyo 7‐3‐1 Hongo, Bunkyo‐ku Tokyo 113‐0033 Japan
  • Mikiko Kojima
    RIKEN Center for Sustainable Resource Science 1‐7‐22 Suehiro‐cho, Tsurumi‐ku Yokohama 230‐0045 Japan
  • Yumiko Takebayashi
    RIKEN Center for Sustainable Resource Science 1‐7‐22 Suehiro‐cho, Tsurumi‐ku Yokohama 230‐0045 Japan
  • Hitoshi Sakakibara
    RIKEN Center for Sustainable Resource Science 1‐7‐22 Suehiro‐cho, Tsurumi‐ku Yokohama 230‐0045 Japan
  • Hiroo Fukuda
    Department of Biological Sciences Graduate School of Science the University of Tokyo 7‐3‐1 Hongo, Bunkyo‐ku Tokyo 113‐0033 Japan

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<jats:title>Summary</jats:title><jats:p>The post‐embryonic growth of plants requires the activities of apical meristems and lateral meristems. In the meristems, self‐proliferation and differentiation of stem cells is tightly modulated by plant hormone signaling networks and specific transcription factors. Despite extensive studies on stem cell maintenance in plants, the mechanism by which stem cells are initially established is largely unknown. Vascular stem cells consisting of procambial/cambial cells give rise to xylem and phloem cells. In this study, we analyzed the establishment of procambial cells using the <jats:italic>in vitro</jats:italic> culture system <jats:styled-content style="fixed-case">VISUAL</jats:styled-content>, in which mesophyll cells rapidly differentiate into xylem tracheary elements and phloem sieve elements via procambial cells. We found that procambial cell formation in <jats:styled-content style="fixed-case">VISUAL</jats:styled-content> is initiated by light, which can be replaced by application of gibberellin (<jats:styled-content style="fixed-case">GA</jats:styled-content>). Gibberellin was able to promote procambial cell formation through degradation of <jats:styled-content style="fixed-case">DELLA</jats:styled-content>, whereas light did not elevate the endogenous <jats:styled-content style="fixed-case">GA</jats:styled-content> content. Indeed, light in combination with bikinin reduced the accumulation of <jats:styled-content style="fixed-case">DELLA</jats:styled-content> protein in <jats:styled-content style="fixed-case">VISUAL</jats:styled-content>. Consistently, overexpression of a constitutively active <jats:styled-content style="fixed-case">DELLA</jats:styled-content> protein repressed vascular cell differentiation even under light. These combined results suggest that <jats:styled-content style="fixed-case">DELLA</jats:styled-content> signaling suppresses procambial cell formation during vascular development in <jats:styled-content style="fixed-case">VISUAL</jats:styled-content>.</jats:p>

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