An Expanded Palette of Genetically Encoded Ca <sup>2+</sup> Indicators

  • Yongxin Zhao
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
  • Satoko Araki
    Research Institute for Electronic Science, Hokkaido University, Kita 20, Nishi 10 Kita-ku, Sapporo 001-0020, Japan.
  • Jiahui Wu
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
  • Takayuki Teramoto
    Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
  • Yu-Fen Chang
    Research Institute for Electronic Science, Hokkaido University, Kita 20, Nishi 10 Kita-ku, Sapporo 001-0020, Japan.
  • Masahiro Nakano
    Research Institute for Electronic Science, Hokkaido University, Kita 20, Nishi 10 Kita-ku, Sapporo 001-0020, Japan.
  • Ahmed S. Abdelfattah
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
  • Manabi Fujiwara
    Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
  • Takeshi Ishihara
    Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
  • Takeharu Nagai
    Research Institute for Electronic Science, Hokkaido University, Kita 20, Nishi 10 Kita-ku, Sapporo 001-0020, Japan.
  • Robert E. Campbell
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

Abstract

<jats:p> Directed protein evolution provides a series of fluorescent protein-based indicators for multicolor Ca2 <jats:sup>+</jats:sup> imaging. </jats:p>

Journal

  • Science

    Science 333 (6051), 1888-1891, 2011-09-30

    American Association for the Advancement of Science (AAAS)

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