Stabilization Energy of the Catalytic Core of the <i>Tetrahymena</i> Ribozyme

  • Naoki Sugimoto
    Department of Chemistry, Faculty of Science, Konan University
  • Muneo Sasaki
    Department of Chemistry, Faculty of Science, Konan University

Abstract

<jats:title>Abstract</jats:title> <jats:p>The stabilization energy of a catalytic core of the Tetrahymena ribozyme has been calculated according to a nearest-neighbor model for RNA duplex formation. The results suggested that the high activity of the mutant ribozyme lacking the P9 region was due to the formation of a stabilized secondary structure by the approach between the active and substrate-binding sites.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 20 (3), 345-348, 1991-03-01

    Oxford University Press (OUP)

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