Cholesterol Suppresses Pressure-induced Interdigitation of Dipalmitoylphosphatidylcholine Bilayer Membrane

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  • Nobutake Tamai
    Department of Life System, Institute of Technology and Science, The University of Tokushima
  • Takayuki Matsui
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
  • Nobutaka Moribayashi
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
  • Masaki Goto
    Department of Life System, Institute of Technology and Science, The University of Tokushima
  • Hitoshi Matsuki
    Department of Life System, Institute of Technology and Science, The University of Tokushima
  • Shoji Kaneshina
    Department of Life System, Institute of Technology and Science, The University of Tokushima

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<jats:title>Abstract</jats:title> <jats:p>We investigated the effect of cholesterol on the pressure-induced interdigitation of dipalmitoylphosphatidylcholine (DPPC) bilayer membrane by fluorescence technique using 6-propionyl-2-(dimethylamino)naphthalene (Prodan) as a probe. The interdigitation pressure (IP), minimum pressure required for the bilayer interdigitation, was elevated with increasing cholesterol composition (Cch) up to ca. 2 mol %. Further increase of Cch did not give any effect on the IP value. Finally, the interdigitation could not be observed at Cch=8 mol %. Constructed pressure–Cch phase diagram at 50 °C suggests that the retardation and the abolition of the interdigitation are attributable to an interference effect and eventual formation of ordered molecular orientation induced by cholesterol.</jats:p>

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  • Chemistry Letters

    Chemistry Letters 37 (6), 604-605, 2008-05-03

    Oxford University Press (OUP)

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