Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia

DOI PDF 被引用文献22件 参考文献28件
  • Saion Chatterjee
    Alfred Health, Melbourne, Australia
  • Sanne A.E. Peters
    The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
  • Mark Woodward
    The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
  • Silvia Mejia Arango
    Department of Population Studies, El Colegio de la Frontera Norte, Tijuana, Baja California, México
  • G. David Batty
    Department of Epidemiology and Public Health, University College London, London, U.K.
  • Nigel Beckett
    Section of Care of the Elderly, Faculty of Medicine, Imperial College London, London, U.K.
  • Alexa Beiser
    Department of Biostatistics, Boston University School of Public Health, Boston, MA
  • Amy R. Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL
  • Paul K. Crane
    Department of Medicine, University of Washington, Seattle, WA
  • Mary Haan
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA
  • Linda B. Hassing
    Department of Psychology, Gothenburg University, Gothenburg, Sweden
  • Kathleen M. Hayden
    Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC
  • Yutaka Kiyohara
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Eric B. Larson
    Group Health Research Institute, Seattle, WA
  • Chung-Yi Li
    Department and Graduate Institute of Public Health, College of Medicine, National Cheng Kung University, Tainan, Tawian
  • Toshiharu Ninomiya
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Tomoyuki Ohara
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Ruth Peters
    Section of Care of the Elderly, Faculty of Medicine, Imperial College London, London, U.K.
  • Tom C. Russ
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, U.K.
  • Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, MA
  • Bjørn H. Strand
    Norwegian Institute of Public Health, Oslo, Norway
  • Rod Walker
    Group Health Research Institute, Seattle, WA
  • Weili Xu
    Aging Research Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institute and Stockholm University, Stockholm, Sweden
  • Rachel R. Huxley
    The George Institute for Global Health, University of Sydney, Sydney, Australia

抄録

<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a meta-analysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45–1.80]; men: pooled RR 1.58 [95% CI 1.38–1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86–2.94) in women and 1.73 (95% CI 1.61–1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35–1.73) in women and 1.49 (95% CI 1.31–1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08–1.30]; P &lt; 0.001).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.</jats:p> </jats:sec>

収録刊行物

  • Diabetes Care

    Diabetes Care 39 (2), 300-307, 2015-12-17

    American Diabetes Association

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