A Combinational Effect of “Bulk” and “Surface” Shape‐Memory Transitions on the Regulation of Cell Alignment
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- Koichiro Uto
- International Research Center for Materials Nanoarchitectonics (WPI‐MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba 305‐0044 Japan
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- Takao Aoyagi
- International Research Center for Materials Nanoarchitectonics (WPI‐MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba 305‐0044 Japan
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- Cole A. DeForest
- Department of Chemical Engineering University of Washington 4000 15<sup>th</sup> Ave NE Seattle WA 98195 USA
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- Allan S. Hoffman
- Department of Bioengineering University of Washington 3720 15<sup>th</sup> Ave NE Seattle WA 98195 USA
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- Mitsuhiro Ebara
- International Research Center for Materials Nanoarchitectonics (WPI‐MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba 305‐0044 Japan
書誌事項
- 公開日
- 2017-02-07
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/adhm.201601439
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>A novel shape‐memory cell culture platform has been designed that is capable of simultaneously tuning surface topography and dimensionality to manipulate cell alignment. By crosslinking poly(ε‐caprolactone) (PCL) macromonomers of precisely designed nanoarchitectures, a shape‐memory PCL with switching temperature near body temperature is successfully prepared. The temporary strain‐fixed PCLs are prepared by processing through heating, stretching, and cooling about the switching temperature. Temporary nanowrinkles are also formed spontaneously during the strain‐fixing process with magnitudes that are dependent on the applied strain. The surface features completely transform from wrinkled to smooth upon shape‐memory activation over a narrow temperature range. Shape‐memory activation also triggers dimensional deformation in an initial fixed strain‐dependent manner. A dynamic cell‐orienting study demonstrates that surface topographical changes play a dominant role in cell alignment for samples with lower fixed strain, while dimensional changes play a dominant role in cell alignment for samples with higher fixed strain. The proposed shape‐memory cell culture platform will become a powerful tool to investigate the effects of spatiotemporally presented mechanostructural stimuli on cell fate.</jats:p>
収録刊行物
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- Advanced Healthcare Materials
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Advanced Healthcare Materials 6 (9), 1601439-, 2017-02-07
Wiley
