Membrane‐mediated regulation of vascular identity

DOI Web Site Web Site 被引用文献2件 参考文献210件 オープンアクセス
  • Takuya Hashimoto
    The Department of Surgery and the Vascular Biology and Therapeutics Program Yale University, New Haven Connecticut
  • Masayuki Tsuneki
    Division of Cancer Biology National Cancer Center Research Institute, Tokyo Japan
  • Trenton R. Foster
    The Department of Surgery and the Vascular Biology and Therapeutics Program Yale University, New Haven Connecticut
  • Jeans M. Santana
    The Department of Surgery and the Vascular Biology and Therapeutics Program Yale University, New Haven Connecticut
  • Hualong Bai
    The Department of Surgery and the Vascular Biology and Therapeutics Program Yale University, New Haven Connecticut
  • Mo Wang
    The Department of Surgery and the Vascular Biology and Therapeutics Program Yale University, New Haven Connecticut
  • Haidi Hu
    The Department of Surgery and the Vascular Biology and Therapeutics Program Yale University, New Haven Connecticut
  • Jesse J. Hanisch
    The Department of Surgery and the Vascular Biology and Therapeutics Program Yale University, New Haven Connecticut
  • Alan Dardik
    The Department of Surgery and the Vascular Biology and Therapeutics Program Yale University, New Haven Connecticut

説明

<jats:title>Abstract</jats:title><jats:p>Vascular diseases span diverse pathology, but frequently arise from aberrant signaling attributed to specific membrane‐associated molecules, particularly the Eph‐ephrin family. Originally recognized as markers of embryonic vessel identity, Eph receptors and their membrane‐associated ligands, ephrins, are now known to have a range of vital functions in vascular physiology. Interactions of Ephs with ephrins at cell‐to‐cell interfaces promote a variety of cellular responses such as repulsion, adhesion, attraction, and migration, and frequently occur during organ development, including vessel formation. Elaborate coordination of Eph‐ and ephrin‐related signaling among different cell populations is required for proper formation of the embryonic vessel network. There is growing evidence supporting the idea that Eph and ephrin proteins also have postnatal interactions with a number of other membrane‐associated signal transduction pathways, coordinating translation of environmental signals into cells. This article provides an overview of membrane‐bound signaling mechanisms that define vascular identity in both the embryo and the adult, focusing on Eph‐ and ephrin‐related signaling. We also discuss the role and clinical significance of this signaling system in normal organ development, neoplasms, and vascular pathologies. Birth Defects Research (Part C) 108:65–84, 2016. © 2016 Wiley Periodicals, Inc.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (210)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ