Potential roles of metalloproteinases of endometrium‐derived exosomes in embryo‐maternal crosstalk during implantation
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- Zeinab Latifi
- Animal Resource Science Center Graduate School of Agricultural and Life Sciences The University of Tokyo Ibaraki Japan
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- Amir Fattahi
- Department of Reproductive Biology Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences Tabriz Iran
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- Ali Ranjbaran
- Women's Reproductive Health Research Center Tabriz University of Medical Sciences Tabriz Iran
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- Hamid Reza Nejabati
- Women's Reproductive Health Research Center Tabriz University of Medical Sciences Tabriz Iran
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- Kazuhiko Imakawa
- Animal Resource Science Center Graduate School of Agricultural and Life Sciences The University of Tokyo Ibaraki Japan
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説明
<jats:sec><jats:label/><jats:p>During embryo implantation, crosstalk between the endometrial epithelium and the blastocyst, especially the trophoblasts, is a prerequisite for successful implantation. During this crosstalk, various molecular and functional changes occur to promote synchrony between the embryo and the endometrium as well as the uterine cavity microenvironment. In the past few years, growing evidence has shown that endometrium‐derived exosomes play pivotal roles in the embryonic‐maternal crosstalk during implantation, although the exact mechanism of this crosstalk has yet to be determined. The presence of metalloproteinases has been reported in endometrium‐derived exosomes, implying the importance of these enzymes in exosome‐based crosstalk. Thus, in this review, we describe the potential roles of the metalloproteinases of endometrium‐derived exosomes in promoting embryo attachment and implantation. This study could provide a better understanding of the potential roles of exosomal metalloproteinases in embryo implantation and pave the way for developing novel exosome‐based regulatory agents to support early pregnancy.</jats:p></jats:sec>
収録刊行物
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- Journal of Cellular Physiology
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Journal of Cellular Physiology 233 (6), 4530-4545, 2017-12-26
Wiley
