Epigenetic regulation of neural stem cell fate during corticogenesis

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  • Chai MuhChyi
    Laboratory of Molecular Neuroscience Graduate School of Biological Sciences Nara Institute of Science and Technology Takayama 8916‐5 Ikoma Nara 630‐0192 Japan
  • Berry Juliandi
    Laboratory of Molecular Neuroscience Graduate School of Biological Sciences Nara Institute of Science and Technology Takayama 8916‐5 Ikoma Nara 630‐0192 Japan
  • Taito Matsuda
    Laboratory of Molecular Neuroscience Graduate School of Biological Sciences Nara Institute of Science and Technology Takayama 8916‐5 Ikoma Nara 630‐0192 Japan
  • Kinichi Nakashima
    Laboratory of Molecular Neuroscience Graduate School of Biological Sciences Nara Institute of Science and Technology Takayama 8916‐5 Ikoma Nara 630‐0192 Japan

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<jats:title>Abstract</jats:title><jats:p>The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs.</jats:p>

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