1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators
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説明
The nuclear receptors liver X receptor (LXR) α and LXRβ are involved in the regulation of lipid metabolism, inflammation, immunity, cellular proliferation, and apoptosis. Oxysterols are endogenous LXR ligands, and also interact with other nuclear and membrane receptors. We previously reported that a phytosterol derivative with a 1α-hydroxy group acts as a potent LXR agonist with intestine-selective action and that 25-hydroxy and 26/27-hydroxy metabolites of 7-dehydrocholesterol (7-DHC) exhibit partial LXR agonism. In this study, we report that 1α-hydroxy derivatives of 7-DHC, 1α-OH-7-DHC and 1,25-(OH)
収録刊行物
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- The Journal of Steroid Biochemistry and Molecular Biology
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The Journal of Steroid Biochemistry and Molecular Biology 172 136-148, 2017-09
Elsevier BV
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キーワード
- Keratinocytes
- Hydrocarbons, Fluorinated
- Structure-Activity Relationship
- Dehydrocholesterols
- Calcitriol
- Genes, Reporter
- Cell Line, Tumor
- Humans
- Luciferases
- Liver X Receptors
- Sulfonamides
- Hep G2 Cells
- Molecular Docking Simulation
- Cholesterol
- HEK293 Cells
- Gene Expression Regulation
- Organ Specificity
- MCF-7 Cells
- Receptors, Calcitriol
- Caco-2 Cells
- Signal Transduction
詳細情報 詳細情報について
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- CRID
- 1360285707300452480
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- ISSN
- 09600760
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- PubMed
- 28736297
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
