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Association between lymphangiogenesis-/micrometastasis- and adhesion-related molecules in resected stage I NSCLC
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Description
The purpose of this study was to clarify the role and clinical significance of lymphangiogenesis/micrometastases and adhesion molecules in resected stage I non-small cell lung cancer (NSCLC).Immunohistochemical (IHC) staining was used to analyze the protein expression of vascular endothelial growth factor-C (VEGF-C), VEGF, E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin in paraffin-embedded tumor samples from 117 well-characterized stage I NSCLC patients and to compare the protein expression, clinical variables and survival outcome. As a micrometastatic parameter in lymph nodes (LNs), cytokeratin (CK) staining was performed.The positive expression of VEGF-C and VEGF were detected in 54 (48.7%) and 86 (73.5%), respectively. We identified micrometastatic tumor cells in pathological N0 LNs in 34 (29.1%) of 117 patients. E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin were identified in 70 (59.8%), 41 (35.0%), 83 (70.9%), and 61 (52.1%) specimens, respectively. The VEGF-C expression was found more frequently in squamous cell carcinoma (SQ) and in the tumors with negative expression of beta-catenin than counter features. The VEGF expression was found more frequently in the tumors with a negative expression of E-cadherin. Micrometastasis was found more frequently in a pathological T2 status and in the tumors with a negative expression of alpha-catenin. Beta-catenin and gamma-catenin expressions were found less and more frequently in SQ, respectively. A univariate and multivariate survival analysis demonstrated that old age, pathological T2 status, and micrometastasis were independently associated with an increased risk of poor survival in the patients who underwent a surgical resection of stage I NSCLC.Complicated relationships exist between lymphangiogenesis/micrometastases and adhesion molecules with a specific histology. The detection of lymph nodal micrometastasis by CK may therefore be a useful marker for predicting a poor prognosis in patients who undergo a complete resection of stage I NSCLC.
Journal
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- Lung Cancer
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Lung Cancer 70 (3), 320-328, 2010-12
Elsevier BV
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Keywords
- Male
- Lung Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Biomarkers, Tumor
- Cell Adhesion
- Humans
- Lymphangiogenesis
- Aged
- Neoplasm Staging
- Aged, 80 and over
- Vascular Endothelial Growth Factors
- Catenins
- Middle Aged
- Cadherins
- Immunohistochemistry
- Gene Expression Regulation, Neoplastic
- Lymphatic Metastasis
- Keratins
- Female
- Lymph Nodes
Details 詳細情報について
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- CRID
- 1360285707327492736
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- ISSN
- 01695002
- http://id.crossref.org/issn/01695002
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- PubMed
- 20363046
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- Article Type
- journal article
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- Data Source
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- Crossref
- KAKEN
- OpenAIRE