Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6
説明
The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C_LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis.
収録刊行物
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- Journal of Investigative Dermatology
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Journal of Investigative Dermatology 131 (5), 1105-1109, 2011-05
Elsevier BV
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キーワード
- Adult
- Male
- Adolescent
- Dermatology
- HLA-C Antigens
- Settore MED/03 - GENETICA MEDICA
- Biochemistry
- Polymorphism, Single Nucleotide
- White People
- Article
- Young Adult
- Asian People
- Gene Frequency
- Risk Factors
- Cornified Envelope Proline-Rich Proteins
- Humans
- Psoriasis
- Genetic Predisposition to Disease
- Molecular Biology
- Sequence Deletion
- Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1]
- Epistasis, Genetic
- Cell Biology
- Chromosomes, Human, Pair 1
- Genetic Loci
- Female
- N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity
- Gene Deletion
詳細情報 詳細情報について
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- CRID
- 1360285708388477440
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- NII論文ID
- 20001433327
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- HANDLE
- 2108/134268
- 2066/96094
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- ISSN
- 0022202X
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- データソース種別
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- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE