Characterization of an RNA receptor motif that recognizes a GCGA tetraloop

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  • Airi Furukawa
    Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan
  • Takaya Maejima
    Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan
  • Shigeyoshi Matsumura
    Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan
  • Yoshiya Ikawa
    Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan

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<jats:title>Abstract</jats:title> <jats:p>Tertiary interactions between a new RNA motif and RNA tetraloops were analyzed to determine whether this new motif shows preference for a GCGA tetraloop. In the structural context of a ligase ribozyme, this motif discriminated GCGA loop from 3 other tetraloops. The affinity between the GCGA loop and its receptor is strong enough to carry out the ribozyme activity.</jats:p>

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