Japanese Rice Wine can reduce psychophysical stress-induced depression-like behaviors and Fos expression in the trigeminal subnucleus caudalis evoked by masseter muscle injury in the rats

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  • Yosuke Nakatani
    Division of Oral Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
  • Yoshito Kakihara
    Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
  • Shiho Shimizu
    Division of Oral Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
  • Masayuki Kurose
    Division of Oral Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
  • Tsutomu Sato
    Department of Applied Biological Chemistry, Faculty of Agriculture, Graduate School of Science and Technology, Niigata University, Niigata City, Japan
  • Mitsuoki Kaneoke
    Sakeology Center, Niigata University, Niigata City, Japan
  • Makio Saeki
    Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
  • Ritsuo Takagi
    Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
  • Kensuke Yamamura
    Division of Oral Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
  • Keiichiro Okamoto
    Division of Oral Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan

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<jats:title>ABSTRACT</jats:title> <jats:p>We determined if Japanese Rice Wine (Sake) had inhibitory effects on stress-induced enhancement of masseter muscle (MM) nociception in the rats. Male rats were subjected to the repeated forced swim stress (FS) or sham conditionings from Day −3 to −1. Daily administration of Sake or saline was conducted after each stress conditioning. At Day 0 the number of Fos positive cells, a marker for neural activity, was quantified at the trigeminal subnucleus caudalis (Vc) region by MM injury with formalin. FS increased MM-evoked Fos expression in the Vc region, which was inhibited by Sake compared to saline administration. Sake did not alter the number of Fos positive cells under sham conditions, indicating that inhibitory roles of Sake on neural activity in the Vc region were seen under FS conditions. These findings indicated that Sake had inhibitory roles on stress-induced MM nociception at the Vc region in our experimental conditions.</jats:p>

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