Specific delivery of transport vesicles mediated by complementary recognition of DNA signals with membrane-bound oligonucleotide lipids

DOI Web Site 被引用文献2件 参考文献17件
  • Kazuma Yasuhara
    Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Zhong-Hua Wang
    Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Takahiro Ishikawa
    Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Jun-Ichi Kikuchi
    Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Yoshihiro Sasaki
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo, Japan
  • Satoshi Hiyama
    Research Laboratories, NTT DOCOMO, Inc., Yokosuka, Kanagawa, Japan
  • Yuki Moritani
    Research Laboratories, NTT DOCOMO, Inc., Yokosuka, Kanagawa, Japan
  • Tatsuya Suda
    Department of Information and Computer Science, University of California, Irvine, CA, USA

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Molecular communication is a novel communication paradigm inspired by information processing in biological systems using molecules as information medium. In this study, we achieved the selective propagation of transport vesicles which is an essential technique to establish a molecular communication system using artificial cells. The hybridisation of DNA was employed to conduct a signal-induced delivery of transport vesicles from a sender to a receiver vesicle formed with phospholipids. Oligonucleotide lipids each with a different single-stranded DNA, which acts as recognition tags, were embedded in the sender, receiver and transport vesicles. The addition of a DNA signal with a complementary sequence to connect two oligonucleotide lipids induced the assembly of two types of large unilamellar vesicles as well as recombination of the vesicles. In addition, the selective delivery of transport vesicles between sender and receiver giant vesicles is discussed, based on the results of fluorescence microscopic ob...

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