Triterpenoids from the fruits and leaves of the blackberry (<i>Rubus allegheniensis</i>) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage
書誌事項
- 公開日
- 2014-07-17
- 資源種別
- journal article
- DOI
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- 10.1080/14786419.2014.939087
- 10.6084/m9.figshare.1185543.v1
- 10.6084/m9.figshare.1185543
- 公開者
- Informa UK Limited
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説明
From the methanol extract of the fruits of the blackberry (Rubus allegheniensis Port.), four triterpenoids – pomolic acid (1), tormentic acid (2), euscaphic acid (3) and 1β-hydroxyeuscaphic acid (4) – were isolated, while six triterpenoids – 2, 3, myrianthic acid (5), ziyu glycoside II (6), sericic acid (7) and 19-hydroxy-2,3-secours-12-ene-2,3,28-trioic acid 3-methyl ester (8) – were obtained from the methanol extract of the leaves of this plant. Their structures were determined on the basis of spectral data. Compounds 1–8 were examined for their inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-density lipoproteins at a 50 μM concentration. Among the tested compounds, 1 showed the strongest activity, with the inhibitory effect being 90%. The inhibitory activities of 2–8 were evaluated to be 30%, 32%, 33%, 4%, 48%, 4% and 24%, respectively. Further, the structure–activity relationship of these compounds was investigated.
収録刊行物
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- Natural Product Research
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Natural Product Research 28 (24), 2347-2350, 2014-07-17
Informa UK Limited