Development of the thalamo-dorsal ventricular ridge tract in the Chinese soft-shelled turtle,<i>Pelodiscus sinensis</i>
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- Yasuhiko Tosa
- Graduate School of Science and Engineering; Ehime University; 2-5 Bunkyo-cho Matsuyama 790-8577 Japan
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- Ayako Hirao
- Graduate School of Science and Engineering; Ehime University; 2-5 Bunkyo-cho Matsuyama 790-8577 Japan
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- Ikumi Matsubara
- Graduate School of Science and Engineering; Ehime University; 2-5 Bunkyo-cho Matsuyama 790-8577 Japan
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- Masahumi Kawaguchi
- Graduate School of Medicine and Pharmaceutical Sciences; University of Toyama; 2630 Sugitani Toyama 930-0194 Japan
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- Makiko Fukui
- Graduate School of Science and Engineering; Ehime University; 2-5 Bunkyo-cho Matsuyama 790-8577 Japan
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- Shigeru Kuratani
- Laboratory for Evolutionary Morphology; RIKEN Center for Developmental Biology; 2-2-3 Minatojima-minami, Chuoku; Kobe Hyogo 650-0047 Japan
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- Yasunori Murakami
- Graduate School of Science and Engineering; Ehime University; 2-5 Bunkyo-cho Matsuyama 790-8577 Japan
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説明
With the exception of that from the olfactory system, the vertebrate sensory information is relayed by the dorsal thalamus (dTh) to be carried to the telencephalon via the thalamo-telencephalic tract. Although the trajectory of the tract from the dTh to the basal telencephalon seems to be highly conserved among amniotes, the axonal terminals vary in each group. In mammals, thalamic axons project onto the neocortex, whereas they project onto the dorsal pallium and the dorsal ventricular ridge (DVR) in reptiles and birds. To ascertain the evolutionary development of the thalamo-telencephalic connection in amniotes, we focused on reptiles. Using the Chinese soft-shelled turtle (Pelodiscus sinensis), we studied the developmental course of the thalamic axons projecting onto the DVR. We found, during the developmental period when the thalamo-DVR connection forms, that transcripts of axon guidance molecules, including EphA4 and Slit2, were expressed in the diencephalon, similar to the mouse embryo. These results suggest that the basic mechanisms responsible for the formation of the thalamo-telencephalic tract are shared across amniote lineages. Conversely, there was a characteristic difference in the expression patterns of Slit2, Netrin1, and EphrinA5 in the telencephalon between synapsid (mammalian) and diapsid (reptilian and avian) lineages. This indicates that changes in the expression domains of axon guidance molecules may modify the thalamic axon projection and lead to the diversity of neuronal circuits in amniotes.
収録刊行物
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- Development, Growth & Differentiation
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Development, Growth & Differentiation 57 (1), 40-57, 2014-12-14
Wiley