Simple chronic colitis model using hypopigmented mice with a <i>Hermansky–Pudlak syndrome 5</i> gene mutation

DOI Web Site Web Site 被引用文献2件 参考文献30件
  • Yumi Itoh
    Cell Signaling and Metabolic Disease National Institute of Biomedical Innovation Ibaraki Osaka Japan
  • Yasuo Nagaoka
    Department of Life Science and Biotechnology Kansai University Suita Osaka Japan
  • Yoshio Katakura
    Department of Life Science and Biotechnology Kansai University Suita Osaka Japan
  • Hidehisa Kawahara
    Department of Life Science and Biotechnology Kansai University Suita Osaka Japan
  • Hiroshi Takemori
    Cell Signaling and Metabolic Disease National Institute of Biomedical Innovation Ibaraki Osaka Japan

説明

<jats:title>Summary</jats:title><jats:p>Pigmentation in mammals is important for protection of skin and eyes from ultraviolet radiation. Dysregulation of pigmentation is often associated with other conditions that are not directly linked to pigmentation. Here, we isolated spontaneously occurring hypopigmented mice that occasionally experienced severe diarrhea during lactation. Treatment of these mice with dextran sulfate sodium salt, a conventional method to induce acute colitis, caused chronic diarrhea with granulomatous colitis. Gene mapping and sequencing revealed that the mice had a nonsense mutation in the <jats:italic>Hermansky–Pudlak syndrome (Hps)5</jats:italic> gene. As some HPS patients can develop granulomatous colitis, the simple induction of chronic colitis in spontaneously mutated <jats:italic>Hps5</jats:italic>‐deficient mice may become an invaluable model for exploring treatment options in patients with <jats:styled-content style="fixed-case">HPS</jats:styled-content> as well as other patients with inflammatory bowel disease.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (30)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ