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The Role of<i>α</i>-Synuclein and LRRK2 in Tau Phosphorylation
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- Fumitaka Kawakami
- Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 2520373, Japan
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- Takafumi Ichikawa
- Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 2520373, Japan
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Description
<jats:p>There is now a considerable body of experimental evidence that Parkinson’s disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of<jats:italic>α</jats:italic>-synuclein and LRRK2 in the abnormal phosphorylation of tau. In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition of<jats:italic>α</jats:italic>-synuclein- and LRRK2-associated tau phosphorylation by HSPs.</jats:p>
Journal
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- Parkinson's Disease
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Parkinson's Disease 2015 1-10, 2015
Wiley
