Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate

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  • Tetsushi Taguchi
    Biomaterials Unit, Nano-Life Field, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Japan
  • Masahiro Okada
    Department of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Japan
  • Yasumichi Kogai
    Department of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Japan
  • Miwa Masuda
    Department of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Japan
  • Yumi Shimomura
    Department of Infectious Diseases, Research Institute, International Medical Center of Japan, Tokyo, Japan
  • Motoki Inoue
    Biomaterials Unit, Nano-Life Field, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Japan
  • Temmei Ito
    Biomaterials Unit, Nano-Life Field, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Japan
  • Takashi Hamahata
    Department of Infectious Diseases, Research Institute, International Medical Center of Japan, Tokyo, Japan
  • Keiji Funatogawa
    Department of Infectious Diseases, Research Institute, International Medical Center of Japan, Tokyo, Japan
  • Teruo Kirikae
    Department of Infectious Diseases, Research Institute, International Medical Center of Japan, Tokyo, Japan
  • Tsutomu Furuzono
    Department of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Japan

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<jats:p> A new material was prepared to reduce catheter infection composed of a flocked silicone sheet (AmTiO<jats:sub>2</jats:sub>NP-F) with TiO<jats:sub>2</jats:sub> nanoparticle–immobilized poly(ethylene terephthalate) fibers modified with surface amino groups. This system was used in conjunction with a tissue adhesive composed of disuccinimidyl tartrate and human serum albumin. At a fixed disuccinimidyl tartrate content of 0.2 mmol in human serum albumin solution, AmTiO<jats:sub>2</jats:sub>NP-F bonded well with collagen-based casing (a model material for skin), with bond strength increasing to a maximum of 38 w/v% human serum albumin. The adhesive bonded AmTiO<jats:sub>2</jats:sub>NP-F to subcutaneous tissue in mice, and infiltration of the tissue into the AmTiO<jats:sub>2</jats:sub>NP-F further increased the bond strength for long-term insertions. The material was degraded within 7 days of implantation, and tissue reaction was mild, while infection was completely prevented. These results indicate that the combined use of AmTiO<jats:sub>2</jats:sub>NP-F and disuccinimidyl tartrate-A for implanted catheters can significantly alleviate the associated risk of infection. </jats:p>

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